Iran launched missile strikes on several major Israeli cities on June 16, 2025, resulting in at least five reported deaths, according to rescue services.

This military response occurred after Israeli airstrikes targeted Iranian territory for the fourth consecutive night, intensifying an already volatile conflict.

Images from Tel Aviv displayed heavily damaged buildings as firefighters conducted searches for potential survivors among the rubble.

Reports indicated that additional missiles impacted cities including Petah Tikva and Bnei Brak, both near Tel Aviv.

Israeli Defense Minister Israel Katz issued a stern warning to Tehran, suggesting that its residents would 'pay the price' for attacks on Israeli civilians.

The Iranian Revolutionary Guards announced that their recent missile operations successfully hit targets in Israel and promised to continue with 'more devastating' operations.

They emphasized that these attacks were conducted 'despite total support from the United States and Western powers for Israel.'

Throughout the night, air raid sirens sounded in Jerusalem, and witnesses reported hearing powerful explosions, causing tremors in residential buildings.

Israeli air defenses were activated, but several missiles remained unchallenged.

In Haifa, heavy smoke was observed rising into the sky following the impact of one missile.

The Magen David Adom, Israel's equivalent of the Red Cross, reported that the Iranian missile assault had caused five deaths and left 92 individuals injured across four central locations.

This round of attacks was in retaliation against Israeli airstrikes that had targeted Iranian facilities during the night, leading to audible explosions in Tehran and the activation of Iranian air defense systems.

Israeli forces confirmed they had struck command centers belonging to Iran's elite Quds Force as well as dozens of missile sites and military installations in western Iran.

Since Friday, these strikes are reported to have resulted in at least 224 deaths and over 1,000 injuries in Iran, according to the Iranian health ministry.

On the Israeli side, retaliatory strikes have reportedly led to at least 18 fatalities and nearly 400 injuries, compiled from police and emergency service reports.

Iranian President Massoud Pezeshkian called for national 'unity' and a collective response to this 'criminal aggression' on Monday.

The ongoing military engagement marks an unprecedented level of confrontation between the two nations, which have historically engaged in proxy wars and periodic skirmishes.

Prior missile attacks had already struck near Tel Aviv over the weekend, causing extensive damage in Bat Yam, south of the city.

Eyewitness Evguenia Doudka described the aftermath, stating, 'There is nothing left, no home, it’s over!' She recounted how her family sought refuge in a shelter, only to find themselves engulfed in dust after an explosive impact.

Israeli airstrikes on Sunday targeted various sites in Tehran, including a residential building that resulted in at least five fatalities.

The Iranian government subsequently announced that mosques, metro stations, and schools would serve as air-raid shelters starting that evening.

The Israeli offensive has reportedly eliminated the three top military officials in Iran and nine nuclear program scientists since Friday.

Long queues of cars were observed on roads leading out of Tehran, as residents sought to flee the escalating conflict.

A local woman, Farzaneh, described her fear and exhaustion, saying they had not rested since Friday due to the continuous noise of explosions, prompting her family to leave the city.

Israel has cited concerns over Iran approaching a 'point of no return' regarding nuclear capabilities, leading to a large-scale aerial campaign aimed at hundreds of military and nuclear sites across Iran.

Despite Iranian assertions denying intentions to develop nuclear weapons, they vowed a 'devastating response' to Israel's attacks and insisted that Israel would soon become 'uninhabitable.'

In addition, the Israeli military targeted Mashhad Airport in northeastern Iran, which lies approximately 2,300 kilometers from Israel.

Israeli Prime Minister Benjamin Netanyahu confirmed on an American news outlet that a primary facility at the Natanz uranium enrichment site had been destroyed, implying that such strikes could lead to a change in Iran's leadership.

European Commission President Ursula von der Leyen stated that she conveyed to Netanyahu that diplomacy represented the best long-term solution regarding Iran.

Meanwhile, U.S. President Donald Trump expressed a desire for both nations to 'reach an agreement,' indicating a potential for American involvement in the unfolding conflict.